The reported resignation was announced Wednesday by The Bureau Newspaper, a media platform with headquarters in Abuja, the Nigerian Federal Capital Territory.
Isaac is said to be planning to commence a new church ministry.
The Bureau Newspaper recalls that Pastor Isaac was announced in September as the national youth pastor of the Youth Alive Fellowship (YAF), the youth arm of the church.
YAF announced this via its official Facebook page, adding that the new youth pastor will take the youthful congregation to glorious heights.
“On behalf of the Youths of Living Faith Church Worldwide, we say a big welcome to our National Youth Pastor, Pastor Isaac Oyedepo as he takes the Youth Alive Fellowship to the next levels of glory,” YAF posted.
Isaac took over from his predecessor, Pastor David Nwabueze, who has been transferred to LFC Nasarawa state.